The costimulatory molecule CD70 is regulated by distinct molecular mechanisms and is associated with overall survival in diffuse large B-cell lymphoma.

@article{Bertrand2013TheCM,
  title={The costimulatory molecule CD70 is regulated by distinct molecular mechanisms and is associated with overall survival in diffuse large B-cell lymphoma.},
  author={Philippe Bertrand and Catherine Maingonnat and Dominique Penther and Suzan Guney and Philippe Ruminy and J M Picquenot and Sylvain Mareschal and M. Mu{\~n}oz Alcantara and Abdelilah Bouzelfen and S. Dubois and Martin Figeac and Christian Bastard and Herv{\'e} Tilly and Fabrice Jardin},
  journal={Genes, chromosomes & cancer},
  year={2013},
  volume={52 8},
  pages={
          764-74
        }
}
  • Philippe Bertrand, Catherine Maingonnat, +11 authors Fabrice Jardin
  • Published in Genes, chromosomes & cancer 2013
  • Biology, Medicine
  • In diffuse large B-cell lymphomas (DLBCL), a recurrent deletion of the 19p13 region has recently been described. CD70 and TNFSF9 genes are suspected tumor suppressor genes, but previous studies suggest an oncogenic role for CD70. Therefore, we studied the consequences of variation in CD70 copy number and epigenetic modifications on CD70 expression. Copy-number variation was investigated in 144 de novo DLBCL tissues by comparative genomic hybridization array and quantitative multiplex PCR. Gene… CONTINUE READING

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