The cost of sensitive response and accurate adaptation in networks with an incoherent type-1 feed-forward loop

@article{Lan2013TheCO,
  title={The cost of sensitive response and accurate adaptation in networks with an incoherent type-1 feed-forward loop},
  author={Ganhui Lan and Yuhai Tu},
  journal={Journal of The Royal Society Interface},
  year={2013},
  volume={10}
}
  • Ganhui Lan, Y. Tu
  • Published 6 October 2013
  • Biology
  • Journal of The Royal Society Interface
The incoherent type-1 feed-forward loop (I1-FFL) is ubiquitous in biological regulatory circuits. Although much is known about the functions of the I1-FFL motif, the energy cost incurred in the network and how it affects the performance of the network have not been investigated. Here, we study a generic I1-FFL enzymatic reaction network modelled after the GEF–GAP–Ras pathway responsible for chemosensory adaptation in eukaryotic cells. Our analysis shows that the I1-FFL network always operates… 

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