The cost of resistance to colistin in Acinetobacter baumannii: a proteomic perspective.

@article{FernndezReyes2009TheCO,
  title={The cost of resistance to colistin in Acinetobacter baumannii: a proteomic perspective.},
  author={Mar{\'i}a Jos{\'e} Fern{\'a}ndez-Reyes and Manuel Rodr{\'i}guez-Falc{\'o}n and Cristina Chiva and Jer{\'o}nimo Pach{\'o}n and David Andreu and Lu{\'i}s Rivas},
  journal={Proteomics},
  year={2009},
  volume={9 6},
  pages={
          1632-45
        }
}
Colistin resistance in Acinetobacter baumannii, a pathogen of clinical concern, was induced in the susceptible strain ATCC 19606 by growth under increasing pressure of the antibiotic, the only drug universally active against multi-resistant clinical strains. In 2-D difference gel electrophoresis (DIGE) experiments, 35 proteins with differences in expression between both phenotypes were identified, most of them appearing as down regulated in the colistin-resistant strain. These include outer… CONTINUE READING

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