The cost of natural selection

@article{Haldane2008TheCO,
  title={The cost of natural selection},
  author={John Burdon Sanderson Haldane},
  journal={Journal of Genetics},
  year={2008},
  volume={55},
  pages={511-524}
}
  • J. Haldane
  • Published 1 December 1957
  • Biology
  • Journal of Genetics
SummaryUnless selection is very intense, the number of deaths needed to secure the substitution, by natural selection, of one gene for another at a locus, is independent of the intensity of selection. It is often about 30 times the number of organisms in a generation. It is suggested that, in horotelic evolution, the mean time taken for each gene substitution is . about 300 generations. This accords with the observed slowness of evolution. 
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