The cost of natural selection

@article{Haldane1957TheCO,
  title={The cost of natural selection},
  author={John Burdon Sanderson Haldane},
  journal={Journal of Genetics},
  year={1957},
  volume={55},
  pages={511-524}
}
  • J. Haldane
  • Published 1 December 1957
  • Biology
  • Journal of Genetics
SummaryUnless selection is very intense, the number of deaths needed to secure the substitution, by natural selection, of one gene for another at a locus, is independent of the intensity of selection. It is often about 30 times the number of organisms in a generation. It is suggested that, in horotelic evolution, the mean time taken for each gene substitution is . about 300 generations. This accords with the observed slowness of evolution. 
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References

SHOWING 1-10 OF 33 REFERENCES

The theory of the evolution of dominance

Fisher's theory appears to stand in need of modification, as the majority of nonlethal mutant genes are present in homozygotes and very few in heterozygotes.

The Effect of Variation of Fitness

In a species in equilibrium variation, some deleterious genes are being weeded out by selection at the same rate as they are produced by mutation and the loss of fitness in the species is roughly equal to the sum of all mutation rates.

Physiological and Evolutionary Theories of Dominance

INTRODUCTION MENDEL found that one member of each of his seven pairs of alternative characters of the pea reappeared in the first cross-bred generation to the complete or nearly complete exclusion of…

The relation between density regulation and natural selection

  • J. Haldane
  • Environmental Science
    Proceedings of the Royal Society of London. Series B - Biological Sciences
  • 1956
Darwin (1859) introduced the notion of natural selection by showing that if the density of a species is to remain steady, most of the individuals in each generation must die prematurely. Nicholson…

THE EVOLUTION OF DOMINANCE

The association of polymorphism, close linkage and dominant variants, including sex-linked dominants in Lebistes, and the stability of the gene ratios in polymorphic species are studied.

Further studies of linkage in the sweet pea

Attention is drawn to the frequency of deficiency of recessive characters in the F2 generation, and it is suggested that the degree of deficiency may possibly be correlated with the age of the recessive mutation in question, the youngest mutations showing the most marked deficiencies, andvice versa.

The theory of selection for melanism in Lepidoptera

  • J. Haldane
  • Biology
    Proceedings of the Royal Society of London. Series B - Biological Sciences
  • 1956
Dr Kettlewell's proof that the dark form carbonaria of Biston betularia has replaced the type, at least in part as the result of selection by bird predators, gives me the right to bring my…

The estimation of viabilities

SummaryIf a sample containsa of a phenotype A andb of a phenotype B, where equal numbers of the two types are expected, thenb/a is a biased estimate of the relative viability of B; andb/(a+ I) is an…

A résumé of investigations on the evolution of melanism in the Lepidoptera

  • H. B. Kettlewell
  • Environmental Science
    Proceedings of the Royal Society of London. Series B - Biological Sciences
  • 1956
In those insects which gain protection from mechanisms other than crypsis (warning, threat and flash coloration), or in those cryptic moths which benefit from resembling dead leaves, the melanics are rare, recessive, sub-lethal and are probably maintained by recurrent mutation.

Further selection experiments on industrial melanism in the Lepidoptera

The results of extensive mark-release-recapture experiments undertaken in 1953 on the Peppered Moth, Biston betularia Linn, and its two melanic forms may be summarised as follows.