The cosecretional maturation of atrial natriuretic factor by primary atrial myocytes.

@article{Sei1992TheCM,
  title={The cosecretional maturation of atrial natriuretic factor by primary atrial myocytes.},
  author={Clara Sei and Galen Hand and Susan F. Murray and Christopher C. Glembotski},
  journal={Molecular endocrinology},
  year={1992},
  volume={6 3},
  pages={309-19}
}
Cardiac myocytes store the 126-amino acid precursor of atrial natriuretic factor (pro-ANF), yet the mature, bioactive 28-amino acid peptide, ANF-(99-126), and the resulting N-terminal product, ANF-(1-98), are the forms of the hormone that are released by the heart and found in the circulation. Although previous studies have shown that the maturation of ANF takes place in the heart, it is not known whether it occurs in or on the myocyte concurrently with secretion, or whether cleavage takes… CONTINUE READING

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