The cortisol and glucocorticoid receptor response to low dose dexamethasone administration in aging combat veterans and holocaust survivors with and without posttraumatic stress disorder

@article{Yehuda2002TheCA,
  title={The cortisol and glucocorticoid receptor response to low dose dexamethasone administration in aging combat veterans and holocaust survivors with and without posttraumatic stress disorder},
  author={Rachel Yehuda and Sarah L. Halligan and Robert A Grossman and Julia A. Golier and Cheryl M. Wong},
  journal={Biological Psychiatry},
  year={2002},
  volume={52},
  pages={393-403}
}
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170 Citations
Highly Influential Citations
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Background Citations
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170 Citations

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TLDR
The data support the hypothesis of enhanced cortisol negative feedback inhibition of ACTH secretion at the level of the pituitary in PTSD, which is implicated as a likely mechanism for this effect.

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TLDR
Comparison of basal cortisol levels in adults with current PTSD and in people without psychiatric disorder revealed that studies assessing plasma or serum showed significantly lower levels in people with PTSD than in controls not exposed to trauma.

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