The cortisol and glucocorticoid receptor response to low dose dexamethasone administration in aging combat veterans and holocaust survivors with and without posttraumatic stress disorder
@article{Yehuda2002TheCA, title={The cortisol and glucocorticoid receptor response to low dose dexamethasone administration in aging combat veterans and holocaust survivors with and without posttraumatic stress disorder}, author={R. Yehuda and S. Halligan and R. Grossman and J. Golier and Cheryl Wong}, journal={Biological Psychiatry}, year={2002}, volume={52}, pages={393-403} }
BACKGROUND
Because alterations in cortisol negative feedback inhibition associated with aging are generally opposite of those observed in posttraumatic stress disorder (PTSD), we examined the cortisol and glucocorticoid receptor (GR) response to dexamethasone (DEX) in older trauma survivors.
METHODS
Twenty-three Holocaust survivors (9 men, 14 women), 27 combat veterans (all male), and 10 comparison subjects (7 men, 3 women) provided samples for plasma or salivary cortisol and glucocorticoid… CONTINUE READING
Topics from this paper
158 Citations
Effects of trauma exposure on the cortisol response to dexamethasone administration in PTSD and major depressive disorder
- Psychology, Medicine
- Psychoneuroendocrinology
- 2004
- 181
Enhanced cortisol suppression in response to dexamethasone administration in traumatized veterans with and without posttraumatic stress disorder
- Psychology, Medicine
- Psychoneuroendocrinology
- 2007
- 150
Age effects on cortisol levels in depressed patients with and without comorbid post-traumatic stress disorder, and healthy volunteers.
- Psychology, Medicine
- Journal of affective disorders
- 2004
- 28
- Highly Influenced
Trauma exposure in relation to basal salivary cortisol and the hormone response to the dexamethasone/CRH test in male railway employees without lifetime psychopathology
- Psychology, Medicine
- Psychoneuroendocrinology
- 2010
- 30
Leukocyte glucocorticoid receptor expression and immunoregulation in veterans with and without post-traumatic stress disorder
- Psychology, Medicine
- Molecular Psychiatry
- 2007
- 96
- PDF
Alterations in Stress Reactivity After Long‐Term Treatment with Paroxetine in Women with Posttraumatic Stress Disorder
- Psychology, Medicine
- Annals of the New York Academy of Sciences
- 2006
- 43
The ACTH response to dexamethasone in PTSD.
- Psychology, Medicine
- The American journal of psychiatry
- 2004
- 171
Salivary Cortisol and Regional Brain Volumes Among Veterans With and Without Posttraumatic Stress Disorder.
- Psychology, Medicine
- Biological psychiatry. Cognitive neuroscience and neuroimaging
- 2017
- 2
- PDF
Cortisol and post-traumatic stress disorder in adults: systematic review and meta-analysis.
- Psychology, Medicine
- The British journal of psychiatry : the journal of mental science
- 2007
- 522
- PDF
Maternal PTSD associates with greater glucocorticoid sensitivity in offspring of Holocaust survivors
- Psychology, Medicine
- Psychoneuroendocrinology
- 2014
- 109
References
SHOWING 1-10 OF 53 REFERENCES
Dose-response changes in plasma cortisol and lymphocyte glucocorticoid receptors following dexamethasone administration in combat veterans with and without posttraumatic stress disorder.
- Psychology, Medicine
- Archives of general psychiatry
- 1995
- 436
Enhanced Dexamethasone Suppression of Plasma Cortisol in Adult Women Traumatized by Childhood Sexual Abuse
- Psychology, Medicine
- Biological Psychiatry
- 1997
- 330
Enhanced suppression of cortisol following dexamethasone administration in posttraumatic stress disorder.
- Psychology, Medicine
- The American journal of psychiatry
- 1993
- 467
Cortisol regulation in posttraumatic stress disorder and major depression: A chronobiological analysis
- Psychology, Medicine
- Biological Psychiatry
- 1996
- 601
Glucocorticoid receptor number and cortisol excretion in mood, anxiety, and psychotic disorders
- Psychology, Medicine
- Biological Psychiatry
- 1993
- 253
Low Urinary Cortisol Excretion in Holocaust Survivors With Posttraumatic Stress Disorder
- Psychology
- 1995
- 253
Low Urinary Cortisol Excretion in Patients with Posttraumatic Stress Disorder
- Medicine
- The Journal of nervous and mental disease
- 1990
- 497
Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
- Psychology, Medicine
- Biological Psychiatry
- 2001
- 1,005
- PDF
Hypothalamo-pituitary-adrenal activity in endogenously depressed post-traumatic stress disorder patients
- Psychology, Medicine
- Psychoneuroendocrinology
- 1989
- 81
Basal cortisol, dexamethasone suppression of cortisol, and MHPG in adolescents after the 1988 earthquake in Armenia.
- Psychology, Medicine
- The American journal of psychiatry
- 1996
- 299