The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden

  title={The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden},
  author={Stephan Claes and Sandra M. Villafuerte and Thomas Forsgren and Sam Sluijs and Jurgen Del-Favero and Rolf Adolfsson and Christine Van Broeckhoven},
  journal={Biological Psychiatry},

Single nucleotide polymorphism analysis of corticotropin-releasing factor-binding protein gene in bipolar disorder

This study in an isolated Swedish population does not support a role for the CRF-BP gene in the vulnerability for bipolar disorder and the haplotype block structure of the gene was considered.

Corticotropin Releasing Factor Binding Protein as a Novel Target to Restore Brain Homeostasis: Lessons Learned From Alcohol Use Disorder Research

A narrative review focuses on molecular mechanisms related to the role of CRFBP in the progression of addictive and psychiatric disorders, biological aging, and age-related neurodegenerative disease.

Genetic Variation in Corticotropin Releasing Hormone Binding Protein predicts antidepressant outcomes

Findings suggest that a specific CRHBP SNP, rs28365143, has a role in predicting which patients will improve with antidepressants, and which type of antidepressant may be most effective.

Antidepressant Outcomes Predicted by Genetic Variation in Corticotropin-Releasing Hormone Binding Protein.

Findings suggest that a specific CRHBP SNP, rs28365143, may have a role in predicting which patients will improve with antidepressants and which type of antidepressant may be most effective.

Associations between Single-Nucleotide Polymorphisms in Corticotropin-Releasing Hormone-Related Genes and Irritable Bowel Syndrome

It is suggested that the CRH and CRH-BP genes have no direct effect on IBS status, however, the CRh-BP SNP rs10474485 has some effect onIBS-related emotional abnormalities and resistance to psychosocial stress.

Corticotropin-releasing hormone-binding protein and stress: from invertebrates to humans

The regulation of CRH-BP in response to stress is described, as well as genetic mouse models that have been utilized to elucidate the in vivo role(s) ofCRH- BP in modulating the stress response.

Glucocorticoid Receptor Gene-Based SNP Analysis in Patients with Recurrent Major Depression

This study suggests that polymorphisms in the 5′ region of the NR3C1 gene may play a role in the genetic vulnerability for MDD.



Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins

CORTICOTROPIN-releasing factor (CRF)1, is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRF concentrations in the human peripheral circulation are

The central distribution of a corticotropin-releasing factor (CRF)-binding protein predicts multiple sites and modes of interaction with CRF.

It is indicated that CRF-BP is expressed predominantly in the cerebral cortex, including all major archi-, paleo-, and neocortical fields, and could serve to modify the actions of CRF by intra- and intercellular mechanisms, inCRF-related pathways in the central nervous system and pituitary.

Excess corticotropin releasing hormone-binding protein in the hypothalamic-pituitary-adrenal axis in transgenic mice.

Altered levels of CRH and AVP in response to elevated pituitary CRH-BP clearly demonstrate that regulation of CRh-BP is important in the function of the HPA axis.

Altered hypothalamic-pituitary-adrenocortical regulation in healthy subjects at high familial risk for affective disorders.

This investigation investigated whether the HPA feedback disturbance observed among patients with depression is present in otherwise healthy individuals who are at high risk for psychiatric disorders because they have a first-degree relative with an affective illness.

Altered anxiety and weight gain in corticotropin-releasing hormone-binding protein-deficient mice.

An important role for CRH-BP is suggested in maintaining appropriate levels of these peptides in the central nervous system in maintainingappropriate levels of CRH and/or urocortin levels in the brain of CRh-BP-deficient animals.

Psychoneuroendocrinology of depression. Hypothalamic-pituitary-adrenal axis.

Ultrastructural localization of the corticotropin‐releasing factor–binding protein in rat brain and pituitary

Analysis of the distribution in rat brain and pituitary of the corticotropin‐releasing factor–binding protein (CRF‐BP), a moiety distinct from CRF receptors, suggests that the CRF‐ BP may play a role in processing and degradation of CRF and/or ligand–receptor complexes.

Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders.

Grown nonhuman primates who were exposed as infants to adverse early rearing conditions were studied to determine if long-term alterations of CRF neuronal systems had occurred following the early stressor.

Persistent changes in corticotropin-releasing factor neuronal systems induced by maternal deprivation.

The results indicate that maternal deprivation before weaning in male rats produces effects on CRF neural systems in both the central nervous system and pituitary that are apparent several months later and are probably associated with persistent alterations in behavioral response in adult rats.