The corticotropin-releasing factor1 receptor antagonist R121919 attenuates the behavioral and endocrine responses to stress.

@article{Gutman2003TheCF,
  title={The corticotropin-releasing factor1 receptor antagonist R121919 attenuates the behavioral and endocrine responses to stress.},
  author={David A. Gutman and Michael J. Owens and Kelly H. Skelton and K. V. Thrivikraman and Charles B. Nemeroff},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2003},
  volume={304 2},
  pages={874-80}
}
Corticotropin-releasing factor (CRF) is the major physiological regulator of the hypothalamic-pituitary-adrenal (HPA) axis and serves to coordinate the mammalian endocrine, autonomic, and behavioral responses to stress. Considerable literature from clinical and preclinical data suggests that hypersecretion of hypothalamic and/or extrahypothalamic CRF systems is a major factor in the pathogenesis of affective and anxiety disorders. Based on this premise, a CRF(1) receptor antagonist has been… CONTINUE READING

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