The cortical reaction and development of activation competence in mammalian oocytes.

@article{Ducibella1996TheCR,
  title={The cortical reaction and development of activation competence in mammalian oocytes.},
  author={Tom Ducibella},
  journal={Human reproduction update},
  year={1996},
  volume={2 1},
  pages={29-42}
}
Blocks to polyspermic fertilization are necessary to prevent the incorporation of two sperm nuclei into a zygote's genome, which would result in abnormal development. Many mammalian eggs utilize both an extracellular zona pellucida block to polyspermy and a plasma membrane block. Although little is known about the plasma membrane block in mammals, fertilization results in zona glycoprotein modifications caused by enzymes released by the egg and its cortical granules (CG). This article reviews… CONTINUE READING