The cortical hem regulates the size and patterning of neocortex.

@article{CaroniaBrown2014TheCH,
  title={The cortical hem regulates the size and patterning of neocortex.},
  author={Giuliana Caronia-Brown and Michio Yoshida and Forrest Gulden and Stavroula Assimacopoulos and Elizabeth A Grove},
  journal={Development},
  year={2014},
  volume={141 14},
  pages={
          2855-65
        }
}
The cortical hem, a source of Wingless-related (WNT) and bone morphogenetic protein (BMP) signaling in the dorsomedial telencephalon, is the embryonic organizer for the hippocampus. Whether the hem is a major regulator of cortical patterning outside the hippocampus has not been investigated. We examined regional organization across the entire cerebral cortex in mice genetically engineered to lack the hem. Indicating that the hem regulates dorsoventral patterning in the cortical hemisphere, the… CONTINUE READING

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