The corrinoid cofactor of reductive dehalogenases affects dechlorination rates and extents in organohalide-respiring Dehalococcoides mccartyi

@article{Yan2016TheCC,
  title={The corrinoid cofactor of reductive dehalogenases affects dechlorination rates and extents in organohalide-respiring Dehalococcoides mccartyi},
  author={Jun Yan and Burcu Şimşir and Abigail T. Farmer and Meng Bi and Y. S. Yang and Shawn R Campagna and Frank E L{\"o}ffler},
  journal={The ISME Journal},
  year={2016},
  volume={10},
  pages={1092-1101}
}
Corrinoid auxotrophic organohalide-respiring Dehalococcoides mccartyi (Dhc) strains are keystone bacteria for reductive dechlorination of toxic and carcinogenic chloroorganic contaminants. We demonstrate that the lower base attached to the essential corrinoid cofactor of reductive dehalogenase (RDase) enzyme systems modulates dechlorination activity and affects the vinyl chloride (VC) RDases BvcA and VcrA differently. Amendment of 5,6-dimethylbenzimidazolyl-cobamide (DMB-Cba) to Dhc strain BAV1… CONTINUE READING
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