The correlation of ATP-binding cassette 1 mRNA levels with cholesterol efflux from various cell lines.

@article{Bortnick2000TheCO,
  title={The correlation of ATP-binding cassette 1 mRNA levels with cholesterol efflux from various cell lines.},
  author={Anna E. Bortnick and George H. Rothblat and G W Stoudt and K L Hoppe and Lori J Royer and J Mcneish and Omar L. Francone},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 37},
  pages={28634-40}
}
Studies show that lipid-free apoA-I stimulates release of cholesterol and phospholipid from fibroblasts and macrophages. ATP-binding cassette 1 (ABC1) is implicated in this release and has been identified as the genetic defect in Tangier disease, evidence that ABC1 is critical to the biogenesis of high density lipoprotein. We quantified levels of ABC1 mRNA, protein, and cholesterol efflux from J774 mouse macrophages +/- exposure to a cAMP analog. Up-regulating ABC1 mRNA correlated to increased… CONTINUE READING
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