The correlation between neurotoxicity, aggregative ability and secondary structure studied by sequence truncated Abeta peptides.

@article{Liao2007TheCB,
  title={The correlation between neurotoxicity, aggregative ability and secondary structure studied by sequence truncated Abeta peptides.},
  author={M Q Liao and Y J Tzeng and Lea Y X Chang and Hsien Bin Huang and Tsung H. Lin and Chuan-Jen Chyan and Yi Chin Chen},
  journal={FEBS letters},
  year={2007},
  volume={581 6},
  pages={1161-5}
}
Aggregated beta-amyloid (Abeta) peptides are neurotoxic and cause neuronal death both in vitro and in vivo. Although the formation of a beta-sheet structure is usual required to form aggregates, the relationship between neurotoxicity and the Abeta sequence remains unclear. To explore the correlation between Abeta sequence, secondary structure, aggregative ability, and neurotoxicity, we utilized both full-length and fragment-truncated Abeta peptides. Using a combination of spectroscopic and… CONTINUE READING
Highly Cited
This paper has 122 citations. REVIEW CITATIONS

From This Paper

Topics from this paper.
13 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

123 Citations

0204060'09'12'15'18
Citations per Year
Semantic Scholar estimates that this publication has 123 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…