The core-binding factor β subunit is required for bone formation and hematopoietic maturation

@article{Miller2002TheCF,
  title={The core-binding factor β subunit is required for bone formation and hematopoietic maturation},
  author={Janelle D. Miller and Alan Horner and Terryl Stacy and Christopher H. Lowrey and Jane B Lian and Gary Stein and Glen Nuckolls and Nancy A Speck},
  journal={Nature Genetics},
  year={2002},
  volume={32},
  pages={645-649}
}
Core-binding factor β (Cbfβ) is the common non-DNA-binding subunit of the Cbf family of heterodimeric transcription factors. Mice deficient in Cbfβ have a severe block in fetal liver hematopoiesis at the stage of hematopoietic stem cell (HSC) emergence. Here we show that by providing Cbfβ function in endothelial cells and hematopoietic progenitors we can rescue fetal liver hematopoiesis in Cbfβ-deficient embryos. The rescued mice die at birth, however, with severe defects in skeletal… CONTINUE READING
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