The coordination of signaling during Fc receptor‐mediated phagocytosis

@article{Swanson2004TheCO,
  title={The coordination of signaling during Fc receptor‐mediated phagocytosis},
  author={Joel A. Swanson and Adam D. Hoppe},
  journal={Journal of Leukocyte Biology},
  year={2004},
  volume={76}
}
  • J. Swanson, A. Hoppe
  • Published 1 December 2004
  • Biology, Chemistry
  • Journal of Leukocyte Biology
Phagocytosis by macrophages can be initiated by Fcγ receptors (FcR) in membranes that bind to Fc regions of immunoglobulin G (IgG). Activated FcR transduce signals to cytoplasm, which regulate the internalization of IgG‐coated particles into plasma membrane‐derived vacuoles, phagosomes. Particles internalized by phagocytosis are much larger than FcR, which prompts questions of if and how the receptors are coordinated with each other. FcR‐mediated signal transduction entails recruitment of… 
Coordination of Fc receptor signaling regulates cellular commitment to phagocytosis
TLDR
3′ phosphoinositides, shown previously to be required for phagocytosis, function in a feedback regulatory mechanism affecting late but not early signals, which indicates a mechanism for the coordination of cell movements initiated by receptor signaling.
Microorganisms: Modulation of Phagocytosis and its Mechanisms of Action
TLDR
This review will provide detailed information about trafficking, signaling pathways and mechanisms essential for the macrophage mediated phagocytosis.
Mechanisms of Fc Receptor and Dectin‐1 Activation for Phagocytosis
TLDR
The molecular mechanisms that regulate phagocytosis triggered by Fcγ receptors, which mediate the uptake of immunoglobulin G‐opsonized targets, and Dectin‐1, which is responsible for internalization of fungi with exposed cell wall β‐glucan are described and compared.
TIRF imaging of Fc gamma receptor microclusters dynamics and signaling on macrophages during frustrated phagocytosis
TLDR
It is demonstrated that surface-associated but mobile IgG induces the formation of FcγR microclusters at the pseudopod leading edge, analogous to the process observed for T-cell receptors.
Phagocytosis in Macrophages Lacking Cbl Reveals an Unsuspected Role for Fcγ Receptor Signaling and Actin Assembly in Target Binding1
TLDR
Findings suggest that dynamic engagement of TKs and the cytoskeleton enables macrophages to serve as cellular “Venus fly traps”, with the capacity to capture phagocytic targets under conditions of limiting opsonin density.
Deficiencies of the Lipid-Signaling Enzymes Phospholipase D1 and D2 Alter Cytoskeletal Organization, Macrophage Phagocytosis, and Cytokine-Stimulated Neutrophil Recruitment
TLDR
Macrophages prepared from mice lacking either of the classical PLD isoforms PLD1 or PLD2, or wild-type macrophages whose PLD activity has been pharmacologically inhibited, display isoform-specific actin cytoskeleton abnormalities that likely underlie decreases observed in phagocytic capacity.
Binding of IgG-Opsonized Particles to FcγR Is an Active Stage of Phagocytosis That Involves Receptor Clustering and Phosphorylation1
TLDR
Results indicate that phosphorylation of FcγR and accompanying proteins, dependent on Src kinase activity, facilitates the clustering of activated receptors that is required for efficient particle binding.
Regulation of Phospholipase D by Arf6 during FcγR-Mediated Phagocytosis
TLDR
Results indicate that Arf6 is involved in the regulation of PLD activity and PA synthesis required for efficient phagocytosis.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 126 REFERENCES
A Critical Role for Syk in Signal Transduction and Phagocytosis Mediated by Fcγ Receptors on Macrophages
TLDR
These observations demonstrate that Syk is critical for FcγR-mediated phagocytosis, as well as for signal transduction in macrophages, and provide evidence to support a model of sequential tyrosine kinase activation by F cγR's analogous to models of signaling by the B and T cell antigen receptors.
Dynamics of cytoskeletal proteins during Fcgamma receptor-mediated phagocytosis in macrophages.
TLDR
Results suggest that PI 3-kinase deactivates PAK1, and that this may be needed for phagosome closure.
Rho is Required for the Initiation of Calcium Signaling and Phagocytosis by Fcγ Receptors in Macrophages
TLDR
A role for small GTPases in Fcγ receptor–mediated phagocytosis by leukocytes is identified and Rho was found to be essential for the accumulation of phosphotyrosine and of F-actin aroundphagocytic cups and for F cγ receptor-mediated Ca2+ signaling.
Modular components of phagocytosis
TLDR
This review presents evidence that phagocytosis proceeds in discrete but coordinated stages and emphasizes that the signaling requirements for each of these is distinct.
Contrasting requirements for ubiquitylation during Fc receptor‐mediated endocytosis and phagocytosis
TLDR
A role for ubiquitylation in the endocytosis of immune receptors is demonstrated, and fundamental differences in the mechanisms underlying internalization of a single receptor depending on the size or multiplicity of the ligand complex are revealed.
Differential Involvement of Src Family Kinases in Fcγ Receptor-Mediated Phagocytosis1
TLDR
Findings suggest that Src family kinases are differentially involved in FcγR-signaling and that selective kinases including Lyn and Hck are able to fully transduce phagocytotic signaling.
Fc receptor-mediated phagocytosis
Vav regulates activation of Rac but not Cdc42 during FcγR-mediated phagocytosis
TLDR
It is concluded that Rac is recruited to Fcgamma membrane receptors in its inactive, GDP-bound state and that Vav regulates phagocytosis through subsequent catalysis of GDP/GTP exchange on Rac.
ADP ribosylation factor 6 is activated and controls membrane delivery during phagocytosis in macrophages
TLDR
It is reported that endogenous ADP ribosylation factor 6 (ARF6), a small GTP-binding protein, undergoes a sharp and transient activation in macrophages when phagocytosis was initiated via receptors for the Fc portion of immunoglobulins (FcRs).
Membrane recruitment of Rac1 triggers phagocytosis.
TLDR
The results indicate that by promoting actin polymerisation at particle attachment sites, Rac1 by acting through specific downstream effectors induces plasma membrane remodeling that allows particle internalisation in a membrane-enclosed phagosome.
...
1
2
3
4
5
...