The coordination of signaling during Fc receptor‐mediated phagocytosis

  title={The coordination of signaling during Fc receptor‐mediated phagocytosis},
  author={Joel A. Swanson and Adam D. Hoppe},
  journal={Journal of Leukocyte Biology},
  • J. Swanson, A. Hoppe
  • Published 1 December 2004
  • Biology, Chemistry
  • Journal of Leukocyte Biology
Phagocytosis by macrophages can be initiated by Fcγ receptors (FcR) in membranes that bind to Fc regions of immunoglobulin G (IgG). Activated FcR transduce signals to cytoplasm, which regulate the internalization of IgG‐coated particles into plasma membrane‐derived vacuoles, phagosomes. Particles internalized by phagocytosis are much larger than FcR, which prompts questions of if and how the receptors are coordinated with each other. FcR‐mediated signal transduction entails recruitment of… 
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