The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant

@article{Goldstein2000TheCR,
  title={The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant},
  author={J. Goldstein and N. Waterhouse and P. Juin and G. Evan and D. Green},
  journal={Nature Cell Biology},
  year={2000},
  volume={2},
  pages={156-162}
}
Release of cytochrome c from mitochondria triggers activation of caspase proteases and death of a cell by apoptosis. However, the mechanism and kinetics of cytochrome c release remain unknown. Here we study this event by using green fluorescent protein (GFP)-tagged cytochrome c, and find that the release of cytochrome-c–GFP always precedes exposure of phosphatidylserine and the loss of plasma-membrane integrity — characteristics of apoptotic cells. Once initiated, the release of cytochrome-c… Expand
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