The convergent roles of the nuclear factor I transcription factors in development and cancer.

@article{Chen2017TheCR,
  title={The convergent roles of the nuclear factor I transcription factors in development and cancer.},
  author={Kok-Siong Chen and Jonathan W C Lim and L. Richards and J. Bunt},
  journal={Cancer letters},
  year={2017},
  volume={410},
  pages={
          124-138
        }
}
The nuclear factor I (NFI) transcription factors play important roles during normal development and have been associated with developmental abnormalities in humans. All four family members, NFIA, NFIB, NFIC and NFIX, have a homologous DNA binding domain and function by regulating cell proliferation and differentiation via the transcriptional control of their target genes. More recently, NFI genes have also been implicated in cancer based on genomic analyses and studies of animal models in a… Expand
Variants in nuclear factor I genes influence growth and development
  • M. Zenker, J. Bunt, +9 authors R. Hennekam
  • Medicine, Biology
  • American journal of medical genetics. Part C, Seminars in medical genetics
  • 2019
TLDR
The nuclear factor one (NFI) site‐specific DNA‐binding proteins represent a family of transcription factors that are important for the development of multiple organ systems, including the brain, and the possibility of variants in NFI genes should be considered in individuals with intellectual disability and brain overgrowth. Expand
Targeting Transcription Factors for Cancer Treatment
TLDR
Various ways to target transcription factors in cancer models are discussed: by modulating their expression or degradation, by blocking protein/protein interactions, by targeting the transcription factor itself to prevent its DNA binding either through a binding pocket or at the DNA-interacting site, some of these inhibitors being currently used or evaluated for cancer treatment. Expand
Nuclear Factor I Represses the Notch Effector HEY1 in Glioblastoma1
TLDR
The data indicate that HEY1 is negatively regulated by NFI family members and is associated with increased proliferation, decreased migration, and increased stem cell properties in GBM cells. Expand
Nuclear factor I/B mediates epithelial-mesenchymal transition in human melanoma cells through ZEB1
TLDR
Overall, the present data indicates that NFIB promotes the malignancy of melanoma, particularly EMT, by modulating the ZEB1 axis, such as ZEB2, ATM and CHK1, which may represent a potential molecular therapeutic target in melanoma. Expand
Integrated nuclear proteomics and transcriptomics identifies S100A4 as a therapeutic target in acute myeloid leukemia
TLDR
The first analysis of the nuclear proteome in AML has identified changes in transcription factor expression or regulation of transcription that would not have been seen at the mRNA level and suggest that S100A4 is essential for AML survival and could be a therapeutic target in AMl. Expand
An Integrating Analysis Reveals Key Regulatory Networks in Breast Cancer
TLDR
The dysregulated gene networks and their major TF regulators inferred by this study provide new insights into the regulatory mechanisms of breast cancer and offer new therapeutic targets. Expand
Increased nuclear factor I/B expression in prostate cancer correlates with AR expression
TLDR
The expression pattern of NFIB in primary and castrationresistant prostate cancer and its positive correlation with AR is described and it is demonstrated AR interacts with NFIB. Expand
Increased nuclear factor I/B expression in prostate cancer correlates with AR expression.
TLDR
The expression pattern of NFIB in primary and castration-resistant prostate cancer and its positive correlation with AR is described and an interaction between AR and NFIB is observed through co-immunoprecipitation experiments. Expand
Nuclear factor I/B increases in prostate cancer to support androgen receptor activation
TLDR
It is proposed that one consequence of NFIB over-expression in AR-dependent prostate cancers is increased AR activity as measured by PSA induction. Expand
Transcription factors NFIA and NFIB induce cellular differentiation in high-grade astrocytoma
TLDR
The findings indicate that NFI proteins may have an endogenous pro-differentiative function in astrocytomas, similar to their role in normal development, and establishes a basis for further investigation of targeting NFI-mediated differentiation as a potential differentiation therapy. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 214 REFERENCES
Developmental transcription factor NFIB is a putative target of oncofetal miRNAs and is associated with tumour aggressiveness in lung adenocarcinoma
TLDR
For the first time, a comprehensive characterization of miRNA expression in human fetal lung tissue is described, with subsequent identification of 37 miRNAs in non‐small cell lung cancer (NSCLC) that recapitulate their fetal expression patterns. Expand
Roles of the NFI/CTF gene family in transcription and development.
The Nuclear Factor I (NFI) family of site-specific DNA-binding proteins (also known as CTF or CAAT box transcription factor) functions both in viral DNA replication and in the regulation of geneExpand
The Nuclear Factor I (NFI) Gene Family in Mammary Gland Development and Function
TLDR
The structure and evolution of the Nuclear Factor I gene family is addressed and the role of the NFI transcription factors in the expression of mammary-gland specific proteins, including whey acidic protein and carboxyl ester lipase is examined. Expand
Expression patterns of the four nuclear factor I genes during mouse embryogenesis indicate a potential role in development
TLDR
The differential activation of an NFI‐dependent promoter, together with the expression patterns observed for the four genes, indicate that the NFI proteins may play an important role in regulating tissue‐specific gene expression during mammalian embryogenesis. Expand
Nuclear Factor One Transcription Factors in CNS Development
TLDR
The importance and role of NFI in these processes in the context of several CNS systems including the neocortex, hippocampus, cerebellum, and spinal cord at both cellular and molecular levels are discussed. Expand
Coregulation of genetic programs by the transcription factors NFIB and STAT5.
TLDR
It is proposed that NFIB-STAT5 modules, possibly in conjunction with other transcription factors, control cell-specific genetic programs. Expand
Targets of the nuclear factor I regulon involved in early and late development of postmitotic cerebellar granule neurons
TLDR
Findings indicated that NFI controls CGN postmitotic maturation through a combination of extracellular signaling molecules that operate either continuously to regulate multiple stages of development or primarily at early (Tag‐1) or late (Wnt7a) maturation steps. Expand
The Unique Transcriptional Activation Domain of Nuclear Factor-I-X3 Is Critical to Specifically Induce Marker Gene Expression in Astrocytes*
TLDR
Human NFI-X3, a novel splice variant of the nfix gene, contains a unique transcriptional activation (TA) domain completely conserved in primates that dramatically up-regulated during the differentiation of neural progenitors to astrocytes and precedes the expression ofAstrocyte markers, such as GFAP and SPARCL1. Expand
Nuclear factor I gene expression in the developing forebrain
TLDR
The protein expression of NFIA and NFIB during embryonic and postnatal mouse forebrain development is detailed to suggest that, in addition to regulating the formation of axon guidance substrates, these genes also have cell‐autonomous roles in cortical development. Expand
Essential Role for NFI-C/CTF Transcription-Replication Factor in Tooth Root Development
TLDR
The Nfic mutation is the first mutation described that affects primarily tooth root formation and should greatly aid the understanding of postnatal tooth development. Expand
...
1
2
3
4
5
...