The controversial role of deferiprone in the treatment of thalassemia.

@article{Richardson2001TheCR,
  title={The controversial role of deferiprone in the treatment of thalassemia.},
  author={Des. R. Richardson},
  journal={The Journal of laboratory and clinical medicine},
  year={2001},
  volume={137 5},
  pages={324-9}
}
The role of the orally active iron (Fe) chelator deferiprone in the treatment of beta-thalassemia remains a controversial subject. Despite initial studies showing high Fe chelation efficacy in vitro and also in animals and human subjects, several latter studies have not been so successful. In fact, it has been reported in several clinical trials that deferiprone after long-term treatment had either little effect or actually increased hepatic Fe loading. In addition, an increase in liver… CONTINUE READING