The control structure of the nematode Caenorhabditis elegans: Neuro-sensory integration and proprioceptive feedback.

@article{Fieseler2018TheCS,
  title={The control structure of the nematode Caenorhabditis elegans: Neuro-sensory integration and proprioceptive feedback.},
  author={Charles Fieseler and James M. Kunert-Graf and J. Nathan Kutz},
  journal={Journal of biomechanics},
  year={2018},
  volume={74},
  pages={
          1-8
        }
}
View on PubMed
View With Semantic Reader
14 Citations
Background Citations
4

Figures from this paper

14 Citations

Citation Type

Citation Type

Signatures of proprioceptive control in Caenorhabditis elegans locomotion
TLDR
A computational model is used to identify effects of neural and mechanical modulation on undulatory forward locomotion of Caenorhabditis elegans, with a focus on proprioceptively driven neural control, and reveals a fundamental relationship between body elasticity and environmental drag in determining the dynamics of the body.
A neuromechanical model of multiple network oscillators for forward locomotion in C. elegans
TLDR
A simulation model is used to demonstrate that a repeating neural circuit identified in the worm’s connectome can be chained together to drive forward locomotion on agar in a neuromechanical model of the nematode, in the absence of pacemaker neurons or stretch-receptor feedback.
Nonlinear Control in the Nematode C. elegans
TLDR
A global, nonlinear control model which is minimally parameterized and captures the state transitions described by Markov-switching models with a single dynamical system is proposed, providing an elegant characterization of control in the neuron population dynamics in C. elegans.
Unsupervised learning of control signals and their encodings in Caenorhabditis elegans whole-brain recordings
TLDR
A method to build a global, low-dimensional model of the dynamics, whereby an underlying global linear dynamical system is actuated by temporally sparse control signals which can be predicted both from neurons previously implicated in behavioural transitions but also additional neurons previously unassociated with these behaviours.
Signatures of proprioceptive control in C. elegans locomotion
TLDR
A computational model is used to identify effects of neural and mechanical modulation on undulatory forward locomotion of C. elegans, with a focus on proprioceptively driven neural control, and reveals a fundamental relationship between body elasticity and environmental drag in determining the dynamics of the body.
Three-dimensional simulation of the Caenorhabditis elegans body and muscle cells in liquid and gel environments for behavioural analysis
TLDR
A three-dimensional computational biomechanical model of the Caenorhabditis elegans body based on real anatomical structure is created with a particle system–based simulation engine known as Sibernetic, which implements the smoothed particle–hydrodynamics algorithm.
A Neuromechanical Model of Multiple Network Rhythmic Pattern Generators for Forward Locomotion in C. elegans
TLDR
A simulation model is used to search for parameters of the anatomically constrained ventral nerve cord circuit that, when embodied and situated, can drive forward locomotion on agar, in the absence of pacemaker neurons or stretch-receptor feedback.
Whole animal modeling: piecing together nematode locomotion
Forward and backward locomotion patterns in C. elegans generated by a connectome-based model simulation
TLDR
A connectome-based neural network model consisting of motor neurons of classes A, B, D, AS, and muscle, considering both synaptic and gap connections is presented, which can be trained to reproduce the activity patterns measured for an animal (HRB4 strain).
A recurrent neural network model of C. elegans responses to aversive stimuli
...
1
2
...

References

SHOWING 1-10 OF 56 REFERENCES
Neural control of Caenorhabditis elegans forward locomotion: the role of sensory feedback
TLDR
A simple yet biologically-grounded model for the neural control of Caenorhabditis elegans forward locomotion finds that a minimal circuit of AVB interneurons and B-class motoneurons is sufficient to generate and sustain fictiveforward locomotion patterns that are robust to significant environmental perturbations.
Gait Modulation in C. elegans: An Integrated Neuromechanical Model
TLDR
A model of C. elegans forward locomotion is presented that includes a neuromuscular control system that relies on a sensory feedback mechanism to generate undulations and is integrated with a physical model of the body and environment and reproduces the entire swim-crawl transition with no modulatory mechanism.
Spatiotemporal Feedback and Network Structure Drive and Encode Caenorhabditis elegans Locomotion
Using a computational model of the Caenorhabditis elegans connectome dynamics, we show that proprioceptive feedback is necessary for sustained dynamic responses to external input. This is consistent…
Systems level circuit model of C. elegans undulatory locomotion: mathematical modeling and molecular genetics
TLDR
The model reveals that stretch receptor coupling in the body wall is critical for generation of the neuromuscular wave, and agrees with behavioral data and with other pertinent published data, e.g., that frequency is an increasing function of muscle gap-junction coupling.
Training sensory-motor behavior in the connectome of an artificial C. elegans
The Si elegans Project - The Challenges and Prospects of Emulating Caenorhabditis elegans
TLDR
The overall concepts are presented with special focus on the virtual embodiment of the nematode with a closed-feedback loop, which will result in motor commands at neuromuscular junctions at the hardware-software interface to actuate virtual muscles of the virtual nematodes.
Biological modeling the undulatory locomotion of C. elegans using dynamic neural network approach
A Biologically Accurate 3D Model of the Locomotion of Caenorhabditis Elegans
TLDR
This work presents a biologically accurate, 3-dimensional model of C. elegans that takes into account many facets of the organism including size, shape, weight distribution, muscle placement, and muscle force, and explicitly model the environment of the worm to include factors such as contact, friction, inertia, and gravity.
Structural Properties of the Caenorhabditis elegans Neuronal Network
TLDR
The wiring diagram reported here can help in understanding the mechanistic basis of behavior by generating predictions about future experiments involving genetic perturbations, laser ablations, or monitoring propagation of neuronal activity in response to stimulation.
A C. elegans stretch receptor neuron revealed by a mechanosensitive TRP channel homologue
TLDR
It is shown that trp-4 mutant worms bend their body abnormally, exhibiting a body posture distinct from that of wild-type worms during locomotion, suggesting that TRP-4 is involved in stretch-receptor-mediated proprioception, and that the activity of DVA can be stimulated by body stretch.
...
1
2
3
4
5
...