The control of trunk Hox specificity and activity by Extradenticle.

@article{Ryoo1999TheCO,
  title={The control of trunk Hox specificity and activity by Extradenticle.},
  author={H. Ryoo and R. Mann},
  journal={Genes \& development},
  year={1999},
  volume={13 13},
  pages={
          1704-16
        }
}
We characterize a 37-bp element (fkh[250]) derived from the fork head (fkh) gene, a natural target of the Hox gene Sex combs reduced (Scr). In vitro, Scr cooperatively binds to this DNA with the Hox cofactor Extradenticle (Exd), and the activation of this enhancer in vivo requires Scr and exd. Other Hox/Exd heterodimers do not activate this element in vivo and do not bind this element with high affinity in vitro. The amino-terminal arm of the Scr homeodomain is crucial for the specific… Expand
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