The control of the yeast H2O2 response by the Msn2/4 transcription factors.

@article{Hasan2002TheCO,
  title={The control of the yeast H2O2 response by the Msn2/4 transcription factors.},
  author={Rukhsana Hasan and C. Leroy and A D Isnard and Jean Labarre and Emmanuelle Boy-Marcotte and Michel B. Toledano},
  journal={Molecular microbiology},
  year={2002},
  volume={45 1},
  pages={233-41}
}
We have analysed the contribution of the Msn2/4 transcription factors and the Ras-cAMP-protein kinase A (PKA) pathway to the control of the yeast H2O2 response. Strains deleted for MSN2 and MSN4 are hypersensitive to H2O2, although they can still adapt to this oxidant. They are also unable to induce 27 proteins of the H2O2 stimulon as shown by quantitative two-dimensional gel analysis. This peculiar H2O2 tolerance defect, the nature of the proteins of the Msn2/4 regulon, and the partial overlap… CONTINUE READING
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