The control of seizure-like activity in the rat hippocampal slice.

  title={The control of seizure-like activity in the rat hippocampal slice.},
  author={Houman Khosravani and Peter L. Carlen and Jos{\'e} Luis P{\'e}rez Velazquez},
  journal={Biophysical journal},
  volume={84 1},
The sudden and transient hypersynchrony of neuronal firing that characterizes epileptic seizures can be considered as the transitory stabilization of metastable states present within the dynamical repertoire of a neuronal network. Using an in vitro model of recurrent spontaneous seizures in the rat horizontal hippocampal slice preparation, we present an approach to characterize the dynamics of the transition to seizure, and to use this information to control the activity and avoid the… CONTINUE READING

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