The control of phospholipid methylation by phorbol diesters in differentiating human myeloid HL-60 leukemia cells.

@article{Hoffman1982TheCO,
  title={The control of phospholipid methylation by phorbol diesters in differentiating human myeloid HL-60 leukemia cells.},
  author={Dennis R. Hoffman and Eliezer Huberman},
  journal={Carcinogenesis},
  year={1982},
  volume={3 8},
  pages={875-80}
}
Treatment of human HL-60 promyelocytic leukemia cells with phorbol-12-myristate-13-acetate (PMA), a tumor promoter and inducer of differentiation, stimulated the incorporation of label from L-[methyl-3H]methionine into the cellular phospholipids. Such a stimulation of phospholipid methylation was not observed in an HL-60 cell variant that is resistant to phorbol ester-induced differentiation. Enhanced methylation of phospholipids was detected 6 h after treatment and reached a maximum level of… CONTINUE READING

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