The control of mRNA stability in response to extracellular stimuli.

@article{Shim2002TheCO,
  title={The control of mRNA stability in response to extracellular stimuli.},
  author={Jaekyung Shim and Michael Karin},
  journal={Molecules and cells},
  year={2002},
  volume={14 3},
  pages={323-31}
}
Regulated mRNA turnover is a highly important process in control of gene expression. The specific sequence elements in mRNA modulate the stability of different mRNAs, which varies considerably in response to extracellular stimuli. But the mechanistic basis for regulation of mRNA turnover remains nebulous. Recent works indicate that several signaling pathways have been implicated in regulating the decay of specific mRNA and certain ARE binding proteins mediate rapid degradation of the mRNAs… CONTINUE READING