The control of hyperglycemia in alloxan treated diabetic mice through the stimulation of hepatic insulin synthesis due to the production of nitric oxide.

@article{Ghosh2012TheCO,
  title={The control of hyperglycemia in alloxan treated diabetic mice through the stimulation of hepatic insulin synthesis due to the production of nitric oxide.},
  author={Rajeshwary Ghosh and Pradipta Jana and Asru Kumar Sinha},
  journal={Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association},
  year={2012},
  volume={120 3},
  pages={145-51}
}
OBJECTIVE The hepatocytes from the adult mice when stimulated by glucose had been reported to synthesize and secrete insulin. The feasibility of controlling hyperglycemia in alloxan induced diabetic mice through hepatic synthesis of insulin was studied. MATERIALS AND METHODS Insulin synthesis was determined by in vitro translation of mRNA and by immunohistochemistry of the hepatocytes and assayed by enzyme linked immunosorbent assay (ELISA). Dermcidin isoform 2 (dermcidin) was measured by… CONTINUE READING