The control of glial populations in brain: Changes in astrocyte mitogenic and morphogenic factors in response to injury

@article{NietoSampedro1985TheCO,
  title={The control of glial populations in brain: Changes in astrocyte mitogenic and morphogenic factors in response to injury},
  author={Manuel Nieto-Sampedro and Russel P. Saneto and Jean S. de Vellis and Carl Cotman},
  journal={Brain Research},
  year={1985},
  volume={343},
  pages={320-328}
}
Injury to rat brain induces a 3-10-fold increase in the activity of factors capable of stimulating astrocyte DNA synthesis and cell division in vitro. Maximum mitogenic activity was reached 10-15 days post-lesion in both the tissue surrounding the wound and in the gelfoam filling the wound cavity. Factors capable of transforming the astrocyte morphology from polygonal-flat to fibrous-like (morphogens) could also be observed in brain tissue and showed increased activity beginning at 10 days… CONTINUE READING

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