The control of dopamine neuron development, function and survival: insights from transgenic mice and the relevance to human disease.

@article{Eells2003TheCO,
  title={The control of dopamine neuron development, function and survival: insights from transgenic mice and the relevance to human disease.},
  author={Jeffrey B. Eells},
  journal={Current medicinal chemistry},
  year={2003},
  volume={10 10},
  pages={
          857-70
        }
}
Transgenic technology, especially the use of homologous recombination to disrupt specific genes to produce knockout mice, has added considerably to the understanding of dopamine (DA) neuron develop, survival and function. The current review summarizes results from knockout mice with the target disruption of genes involved in the development of DA neurons (engrailed 1 and 2, lmx1b, and Nurr1), in maintaining DA neurotransmission (tyrosine hydroxylase, vesicular monoamine transporter, DA… CONTINUE READING

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