The control of cell motility and epithelial morphogenesis by Jun kinases.

@article{Xia2004TheCO,
  title={The control of cell motility and epithelial morphogenesis by Jun kinases.},
  author={Ying Xia and Michael Karin},
  journal={Trends in cell biology},
  year={2004},
  volume={14 2},
  pages={
          94-101
        }
}
Originally identified as stress-activated protein kinases that control cell survival and proliferation through transcription factor c-Jun, the Jun N-terminal kinase (JNK) subgroup of MAP kinases (MAPKs) have recently emerged as crucial regulators of cell migration and the morphogenetic movement of epithelial sheets. In Drosophila, a well-orchestrated JNK signaling pathway controls formation of actin stress fibers and cell shape changes, which are required for the sealing of embryonic epidermis… CONTINUE READING

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