The control of Spo11's interaction with meiotic recombination hotspots.

  title={The control of Spo11's interaction with meiotic recombination hotspots.},
  author={Silvia Prieler and Alexandra M. Penkner and Val{\'e}rie Borde and Franz Klein},
  journal={Genes & development},
  volume={19 2},
Programmed double-strand breaks (DSBs), which initiate meiotic recombination, arise through the activity of the evolutionary conserved topoisomerase homolog Spo11. Spo11 is believed to catalyze the DNA cleavage reaction in the initial step of DSB formation, while at least a further 11 factors assist in Saccharomyces cerevisiae. Using chromatin-immunoprecipitation (ChIP), we detected the transient, noncovalent association of Spo11 with meiotic hotspots in wild-type cells. The establishment of… CONTINUE READING

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