The control of HIV transcription: keeping RNA polymerase II on track.

@article{Ott2011TheCO,
  title={The control of HIV transcription: keeping RNA polymerase II on track.},
  author={Melanie Ott and Matthias Geyer and Qiang Zhou},
  journal={Cell host & microbe},
  year={2011},
  volume={10 5},
  pages={426-35}
}
Thirteen years ago, human cyclin T1 was identified as part of the positive transcription elongation factor b (P-TEFb) and the long-sought host cofactor for the HIV-1 transactivator Tat. Recent years have brought new insights into the intricate regulation of P-TEFb function and its relationship with Tat, revealing novel mechanisms for controlling HIV transcription and fueling new efforts to overcome the barrier of transcriptional latency in eradicating HIV. Moreover, the improved understanding… CONTINUE READING
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