The control mechanism for lagging strand polymerase recycling during bacteriophage T4 DNA replication.

Abstract

Given the polarity of DNA duplex, replication by the leading strand polymerase is continuous whereas that by the lagging strand polymerase is discontinuous proceeding through Okazaki fragments. Yet the respective polymerases act processively, implying that the recycling of the lagging strand polymerase is a controlled process. We demonstrate that the rate… (More)

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@article{Yang2006TheCM, title={The control mechanism for lagging strand polymerase recycling during bacteriophage T4 DNA replication.}, author={Jingsong Yang and Scott W. Nelson and Stephen J Benkovic}, journal={Molecular cell}, year={2006}, volume={21 2}, pages={153-64} }