The contributions of lesion laterality and lesion volume to decision-making impairment following frontal lobe damage

  title={The contributions of lesion laterality and lesion volume to decision-making impairment following frontal lobe damage},
  author={Luke Clark and Facundo Manes and Nagui M. Antoun and Barbara Jacquelyn Sahakian and Trevor William Robbins},

Lesion mapping of cognitive control and value-based decision making in the prefrontal cortex

Two distinct functional-anatomical networks were revealed within the PFC: one associated with cognitive control (response inhibition, conflict monitoring, and switching) and a second associated with value-based decision-making, which included the orbitofrontal, ventromedial, and frontopolar cortex.

Distinct roles of prefrontal cortical subregions in the Iowa Gambling Task.

A version of the Iowa Gambling Task specifically modified for event-related functional magnetic resonance imaging is developed and validated, revealing that deciding advantageously under initially ambiguous conditions may require both continuous and dynamic processes involving both the ventral and dorsal prefrontal cortex.

Differential effects of insular and ventromedial prefrontal cortex lesions on risky decision-making

VmPFC damage was associated with increased betting regardless of the odds of winning, consistent with a role of vmPFC in biasing healthy individuals towards conservative options under risk, and patients with insular cortex lesions failed to adjust their bets by the odds on the Cambridge Gamble Task, confirming the necessary role of thevmPFC and insular regions in decision-making under risk.

Social and emotional functions in three patients with medial frontal lobe damage including the anterior cingulate cortex

It is suggested that medial frontal lobe lesions primarily involving the ACC do not appear to critically disrupt motivational decision making or social situation processing, and the ACC plays a role in processing particular types of emotion.

Human lesion studies of ventromedial prefrontal cortex

Impairment of social perception associated with lesions of the prefrontal cortex.

The findings of deficits in social perception after damage to the orbitofrontal cortex extend previous clinical and experimental evidence of damage-related impairment in other aspects of social cognition, such as the ability to accurately evaluate emotional facial expressions.

Impulsivity and risk-taking behavior in focal frontal lobe lesions




Decision-making processes following damage to the prefrontal cortex.

Investigation of cognitive deficits following damage to different sectors of the human prefrontal cortex found that ventral and dorsal aspects of prefrontal cortex must interact in the maintenance of rational and 'non-risky' decision making.

Dissociation Of Working Memory from Decision Making within the Human Prefrontal Cortex

A cognitive and anatomic double dissociation between deficits in decision making (anterior VM) and working memory (right DL/M) is revealed, the first direct evidence of such effects in humans using the lesion method and underscores the special importance of the VM prefrontal region in decisionMaking, independent of a direct role in working memory.

Specific cognitive deficits in mild frontal variant frontotemporal dementia.

It is postulate that, relatively early in the course of the disease, the ventromedial (or orbitofrontal) cortex is a major locus of dysfunction and that this may relate to the behavioural presentation of these patients clinically described in the individual case histories.

Choosing between Small, Likely Rewards and Large, Unlikely Rewards Activates Inferior and Orbital Prefrontal Cortex

The results suggest that decision making recruits neural activity from multiple regions of the inferior PFC that receive information from a diverse set of cortical and limbic inputs, and that the contribution of the orbitofrontal regions may involve processing changes in reward-related information.

Decision-making in mania: a PET study.

Patterns of activation point to abnormal task-related responses in specific frontal regions in manic patients, consistent with neuropsychological observations in patients with lesions in the ventromedial prefrontal cortex, who show similar difficulties with decision-making and provide early evidence for context-specific neural correlates of mania.

Right hemispheric dominance of inhibitory control: an event-related functional MRI study.

  • H. GaravanT. RossE. Stein
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1999
Normal human behavior and cognition are reliant on a person's ability to inhibit inappropriate thoughts, impulses, and actions. The temporal and spatial advantages of event-related functional MRI

Decision-making in a Risk-taking Task: A PET Study

Common inhibitory mechanism in human inferior prefrontal cortex revealed by event-related functional MRI.

The results imply that the right inferior prefrontal area is commonly involved in the inhibition of different targets, i.e. the go response during performance of the go/no-go task and the cognitive set duringperformance of the WCST.

Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans

This work uses a new observer-independent method to relate the degree of damage within a specific prefrontal region to performance on a stop-signal task that is sensitive to the neurodevelopmental aspects of stopping behavior and to attention-deficit/hyperactivity disorder (ADHD) as well as its amelioration by methylphenidate.