The contribution of training to sensitivity in the nociceptive paw-withdrawal test.

@article{Taiwo1989TheCO,
  title={The contribution of training to sensitivity in the nociceptive paw-withdrawal test.},
  author={Yetunde O. Taiwo and Terence J. Coderre and Jon D Levine},
  journal={Brain research},
  year={1989},
  volume={487 1},
  pages={148-51}
}
An important limitation in behavioral tests of the hyperalgesic and analgesic effects of drugs is the low sensitivity of the measuring technique associated with inter- and intra-subject variability. Since familiarity with the experimental situation and novelty of the stimulus significantly influences an animal's behavior, we have tested the hypothesis that intensive training of rats, in the Randall-Selitto paw-withdrawal test, will increase the sensitivity of this test for detecting… CONTINUE READING

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