The contribution of the stomach to ethanol oxidation in the rat.

@article{Caballera1987TheCO,
  title={The contribution of the stomach to ethanol oxidation in the rat.},
  author={Joan Caballer{\'i}a and Enrique Baraona and Charles S. Lieber},
  journal={Life sciences},
  year={1987},
  volume={41 8},
  pages={
          1021-7
        }
}
To estimate the amount of ethanol that can be oxidized in the stomach, steady-state conditions were created in a group of fed rats by giving a loading dose of ethanol (2 g/kg body wt I.V.) followed by continuous infusion either intravenously or intragastrically. The rate of ethanol oxidation was calculated from the rate of infusion required to maintain steady blood levels of approximately 30 mM for at least 3 hours. Gastrointestinal ethanol concentrations and total contents also remained steady… CONTINUE READING