The contribution of the endogenous TRPV1 ligands 9-HODE and 13-HODE to nociceptive processing and their role in peripheral inflammatory pain mechanisms.

@article{Alsalem2013TheCO,
  title={The contribution of the endogenous TRPV1 ligands 9-HODE and 13-HODE to nociceptive processing and their role in peripheral inflammatory pain mechanisms.},
  author={M. A. Alsalem and Amy Wong and Paul J Millns and Pallavi Huma Arya and Michael Siang Liang Chan and Andrew Bennett and David A. Barrett and V. Chapman and David A. Kendall},
  journal={British journal of pharmacology},
  year={2013},
  volume={168 8},
  pages={1961-74}
}
BACKGROUND AND PURPOSE The transient receptor potential vanilloid type 1 (TRPV1) plays a fundamental role in the detection of heat and inflammatory pain responses. Here we investigated the contribution of two potential endogenous ligands [9- and 13- hydroxyoctadecadienoic acid (HODE)] to TRPV1-mediated noxious responses and inflammatory pain responses. EXPERIMENTAL APPROACH 9- and 13-HODE, and their precursor, linoleic acid, were measured in dorsal root ganglion (DRG) neurons and in the… CONTINUE READING
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