The contribution of suilysin to the pathogenesis of Streptococcus suis meningitis.

  title={The contribution of suilysin to the pathogenesis of Streptococcus suis meningitis.},
  author={Dan Takeuchi and Yukihiro Akeda and Tatsuya Nakayama and Anusak Kerdsin and Yasuteru Sano and Takashi Kanda and Shigeyuki Hamada and Surang Dejsirilert and Kazunori Oishi},
  journal={The Journal of infectious diseases},
  volume={209 10},
BACKGROUND Streptococcus suis is an emerging zoonotic pathogen, and causes sepsis and meningitis in humans. Although sequence type (ST) 1 and ST104 strains are capable of causing sepsis, ST1 strains commonly cause meningitis. In this study, we investigated the role of suilysin, a member of cholesterol-dependent cytolysins, in differential pathogenicity between ST1 and ST104 strains. METHODS The levels of transcription and translation of the sly gene and messenger RNA of both ST strains were… 

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