The contribution of raised intraneuronal chloride to epileptic network activity.

@article{Alfonsa2015TheCO,
  title={The contribution of raised intraneuronal chloride to epileptic network activity.},
  author={Hannah Alfonsa and Edward M Merricks and Neela Krushna Codadu and Mark O. Cunningham and Karl Deisseroth and Claudia Racca and Andrew J. Trevelyan},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2015},
  volume={35 20},
  pages={7715-26}
}
Altered inhibitory function is an important facet of epileptic pathology. A key concept is that GABAergic activity can become excitatory if intraneuronal chloride rises. However, it has proved difficult to separate the role of raised chloride from other contributory factors in complex network phenomena, such as epileptic pathology. Therefore, we asked what patterns of activity are associated with chloride dysregulation by making novel use of Halorhodopsin to load clusters of mouse pyramidal… CONTINUE READING
12 Citations
52 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Similar Papers

Loading similar papers…