The contribution of prostaglandins versus prostacyclin in ventricular remodeling during heart failure.


Although the role of Cox-2 in the heart's response to physiologic stress remains controversial (i.e. expression in myocytes versus other resident myocardial cells) the ever expanding role of prostanoids in multiple models of heart failure cannot be denied. Due to the fact that prostanoids are metabolized rather quickly (half life of seconds to minutes) it… (More)
DOI: 10.1016/j.lfs.2011.07.025

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