The contribution of lysosomal trapping in the uptake of desipramine and chloroquine by different tissues.

@article{Daniel1995TheCO,
  title={The contribution of lysosomal trapping in the uptake of desipramine and chloroquine by different tissues.},
  author={W. A. Daniel and M. H. Bickel and Ulrich E. Honegger},
  journal={Pharmacology & toxicology},
  year={1995},
  volume={77 6},
  pages={
          402-6
        }
}
Cationic amphiphilic drugs strongly accumulate in tissues of different organs. Uptake is controlled by two major mechanisms, non-specific binding to membrane phospholipids, and ion-trapping within acidic cellular compartments. The aim of this study was to assess the individual contributions of these two mechanisms on the uptake in vitro of desipramine and chloroquine into tissue slices of control and desipramine-treated rats. Drug uptake into intact slices was compared with uptake into slices… CONTINUE READING

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