The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation.

@article{Workman2001TheCO,
  title={The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation.},
  author={Antony J. Workman and Kathleen Ann Kane and AndrewC. Rankin},
  journal={Cardiovascular research},
  year={2001},
  volume={52 2},
  pages={
          226-35
        }
}
OBJECTIVE To investigate changes in human atrial single cell functional electrophysiological properties associated with chronic atrial fibrillation (AF), and the contribution to these of accompanying ion current changes. METHODS The whole cell patch clamp technique was used to record action potentials, the effective refractory period (ERP) and ion currents, in the absence and presence of drugs, in enzymatically isolated myocytes from 11 patients with chronic (>6 months) AF and 39 patients in… CONTINUE READING
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