The contribution of hepatic inactivation of testosterone to the lowering of serum testosterone levels by ketoconazole.

@article{Wilson2000TheCO,
  title={The contribution of hepatic inactivation of testosterone to the lowering of serum testosterone levels by ketoconazole.},
  author={Vickie S Wilson and Gerald A. LeBlanc},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2000},
  volume={54 1},
  pages={128-37}
}
Hepatic biotransformation processes can be modulated by chemical exposure and these alterations can impact the biotransformation of endogenous substrates. Furthermore, chemically mediated alterations in the biotransformation of endogenous steroid hormones have been implicated as a mechanism by which steroid hormone homeostasis can be disrupted. The fungicide ketoconazole has been shown to lower serum testosterone levels and alter both gonadal synthesis and hepatic inactivation of testosterone… CONTINUE READING