The contribution of genes to osteoarthritis.

  title={The contribution of genes to osteoarthritis.},
  author={Ana M Valdes and Tim D. Spector},
  journal={Rheumatic diseases clinics of North America},
  volume={34 3},
Osteoarthritis (OA) is the most prevalent form of arthritis in the elderly. A large body of evidence, including familial aggregation and classic twin studies, indicates that primary OA has a strong hereditary component that is likely polygenic in nature. Traits related to OA, such as longitudinal changes in cartilage volume and progression of radiographic features, are also under genetic control. In recent years several linkage analyses and candidate gene studies have been performed and… CONTINUE READING