The contribution of classical risk factors to cardiovascular disease in familial hypercholesterolaemia: data in 2400 patients

@article{Jansen2004TheCO,
  title={The contribution of classical risk factors to cardiovascular disease in familial hypercholesterolaemia: data in 2400 patients},
  author={Angelique C M Jansen and Emily S. van Aalst-Cohen and Michael W. T. Tanck and Mieke D. Trip and Peter Lansberg and Anho H. Liem and H W O Roeters van Lennep and Eric J.G. Sijbrands and John J Kastelein},
  journal={Journal of Internal Medicine},
  year={2004},
  volume={256}
}
Objective.  To determine the contribution of classical risk factors to the development of cardiovascular disease (CVD) in patients with heterozygous familial hypercholesterolaemia (FH). 

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TLDR
This project evaluated the efficacy of an individualised tailored lifestyle intervention on lipids, systolic blood pressure, glucose, body mass index (BMI) and waist circumference in people with FH.

Why patients with familial hypercholesterolemia are at high cardiovascular risk? Beyond LDL-C levels.

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References

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TLDR
Prevalence and significance of cardiovascular risk factors in a large cohort of patients with familial hypercholesterolaemia and their impact on mortality and morbidity are studied.

FAMILIAL HYPERCHOLESTEROLEMIA: A GENETIC AND METABOLIC STUDY

Excerpt A large family having familial hypercholesterolemia with a complete pedigree dating from 1732 was studied to define the inheritance, clinical manifestations, and biochemical features. This ...

Risk of fatal coronary heart disease in familial hypercholesterolaemia. Scientific Steering Committee on behalf of the Simon Broome Register Group.

  • Medicine
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TLDR
Familial hypercholesterolaemia is associated with a substantial excess mortality from coronary heart disease in young adults but may not be associated with an additional excess mortality in older patients.

Mortality and Cholesterol Metabolsim in Familial Hypercholesterolemia: Long‐Term Follow‐up of 96 Patients

TLDR
Assessment of the association of different prognostic factors including parameters of cholesterol metabolism with coronary morbidity and mortality in a study group of 96 patients who were heterozygous for familial hypercholesterolemia indicated that also in subjects without baseline myocardial infarction, low bile acid, cholesterol synthesis, or both predicted increased risk of coronary events.

Lp(a) levels and atherosclerotic vascular disease in a sample of patients with familial hypercholesterolemia sharing the same gene defect.

There is considerable variation in the severity of cardiovascular disease among patients with familial hypercholesterolemia (FH). Some reports have suggested that plasma lipoprotein(a) [Lp(a)] levels

Genetic and environmental factors affecting the incidence of coronary artery disease in heterozygous familial hypercholesterolemia.

TLDR
Those factors, which, in addition to total cholesterol levels, are associated with the development of premature coronary atherosclerosis in heterozygous FH are identified.