The contribution of classical risk factors to cardiovascular disease in familial hypercholesterolaemia: data in 2400 patients

@article{Jansen2004TheCO,
  title={The contribution of classical risk factors to cardiovascular disease in familial hypercholesterolaemia: data in 2400 patients},
  author={A. Jansen and E. S. Aalst-Cohen and M. Tanck and M. Trip and P. Lansberg and A. Liem and H. W. O. Roeters van Lennep and E. Sijbrands and J. Kastelein},
  journal={Journal of Internal Medicine},
  year={2004},
  volume={256}
}
Objective.  To determine the contribution of classical risk factors to the development of cardiovascular disease (CVD) in patients with heterozygous familial hypercholesterolaemia (FH). 

Paper Mentions

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ConditionsHeterozygous Familial Hypercholesterolemia
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Prevalence and significance of cardiovascular risk factors in a large cohort of patients with familial hypercholesterolaemia and their impact on mortality and morbidity are studied. Expand
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Excerpt A large family having familial hypercholesterolemia with a complete pedigree dating from 1732 was studied to define the inheritance, clinical manifestations, and biochemical features. This ...
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Additional risk factors increased excess mortality significantly and are highlighted by the presence of premature CAD among first-degree relatives and underscores the need for active identification of all hypercholesterolaemic relatives of such patients. Expand
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TLDR
Those factors, which, in addition to total cholesterol levels, are associated with the development of premature coronary atherosclerosis in heterozygous FH are identified. Expand
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