The contribution of animal models to the understanding of the pathogenesis of type 1 diabetes.

@article{Carnaud1995TheCO,
  title={The contribution of animal models to the understanding of the pathogenesis of type 1 diabetes.},
  author={Claude Carnaud},
  journal={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas},
  year={1995},
  volume={28 8},
  pages={925-9}
}
  • Claude Carnaud
  • Published 1995 in
    Brazilian journal of medical and biological…
The autoimmune nature of insulin-dependent diabetes mellitus (type 1 diabetes) has been definitively established during the past ten years only, owing essentially to the development of the NOD and the BB rat models. Three of the four criterias required for defining an autoimmune disease have been demonstrated in these animal models. IDDM is accompanied by immunological stigmatas including circulating autoantibodies and insulitis (lymphocytic infiltration of the islets of Langerhans), it is… CONTINUE READING