The contribution of alpha2-adrenoceptor and opioid receptor mechanisms to antinociception differs in Lewis and Fischer 344 rats.


Lewis and Fischer 344 (F344) rats differ in their physiological and pharmacological responses to a variety of environmental stimuli, which have been partially attributed to endogenous opioid function. Since opioid and alpha(2)-adrenoceptor mechanisms are closely related, we have comparatively examined the contribution of both systems to antinociception in… (More)


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