The contribution of alpha synuclein to neuronal survival and function – Implications for Parkinson's disease

@inproceedings{Benskey2016TheCO,
  title={The contribution of alpha synuclein to neuronal survival and function – Implications for Parkinson's disease},
  author={Matthew J. Benskey and Ruth G. Perez and Fredric P Manfredsson},
  booktitle={Journal of neurochemistry},
  year={2016}
}
The aggregation of alpha synuclein (α-syn) is a neuropathological feature that defines a spectrum of disorders collectively termed synucleinopathies, and of these, Parkinson's disease (PD) is arguably the best characterized. Aggregated α-syn is the primary component of Lewy bodies, the defining pathological feature of PD, while mutations or multiplications in the α-syn gene result in familial PD. The high correlation between α-syn burden and PD has led to the hypothesis that α-syn aggregation… CONTINUE READING
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