The contribution of alpha-helices to the surface activities of proteins.


The amphilicity of an alpha-helical segment in a protein may be quantitated by calculating its mean helical hydrophobic moment (mu H). For proteins whose hydrophobic interactions with interfaces are mediated by alpha-helices, the surface pressures exerted at the air-water interface correlate with the product (mu H X F) where mu H is the mean helical… (More)