The contribution of age structure to cell population responses to targeted therapeutics.

@article{Gabriel2012TheCO,
  title={The contribution of age structure to cell population responses to targeted therapeutics.},
  author={Pierre Gabriel and Shawn P. Garbett and Vito Quaranta and Darren R Tyson and Glenn F. Webb},
  journal={Journal of theoretical biology},
  year={2012},
  volume={311},
  pages={19-27}
}
Cells grown in culture act as a model system for analyzing the effects of anticancer compounds, which may affect cell behavior in a cell cycle position-dependent manner. Cell synchronization techniques have been generally employed to minimize the variation in cell cycle position. However, synchronization techniques are cumbersome and imprecise and the agents used to synchronize the cells potentially have other unknown effects on the cells. An alternative approach is to determine the age… CONTINUE READING