The contribution of age structure to cell population responses to targeted therapeutics.

@article{Gabriel2012TheCO,
  title={The contribution of age structure to cell population responses to targeted therapeutics.},
  author={Pierre Gabriel and Shawn P. Garbett and Vito Quaranta and Darren R Tyson and Glenn F. Webb},
  journal={Journal of theoretical biology},
  year={2012},
  volume={311},
  pages={19-27}
}
Cells grown in culture act as a model system for analyzing the effects of anticancer compounds, which may affect cell behavior in a cell cycle position-dependent manner. Cell synchronization techniques have been generally employed to minimize the variation in cell cycle position. However, synchronization techniques are cumbersome and imprecise and the… CONTINUE READING