The contribution of activated phagocytes and myelin degeneration to axonal retraction/dieback following spinal cord injury.

@article{McPhail2004TheCO,
  title={The contribution of activated phagocytes and myelin degeneration to axonal retraction/dieback following spinal cord injury.},
  author={Lowell T. McPhail and David P. Stirling and Wolfram Tetzlaff and Jacek M. Kwiecien and Matt S. Ramer},
  journal={The European journal of neuroscience},
  year={2004},
  volume={20 8},
  pages={1984-94}
}
Myelin-derived molecules inhibit axonal regeneration in the CNS. The Long-Evans Shaker rat is a naturally occurring dysmyelinated mutant, which although able to express the components of myelin lacks functional myelin in adulthood. Given that myelin breakdown exposes axons to molecules that are inhibitory to regeneration, we sought to determine whether injured dorsal column axons in a Shaker rat would exhibit a regenerative response absent in normally myelinated Long-Evans (control) rats… CONTINUE READING

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